Missense mutations of PBP2a are associated with reduced susceptibility to ceftaroline and ceftobiprole in African MRSA
نویسندگان
چکیده
منابع مشابه
PBP2a substitutions linked to ceftaroline resistance in MRSA isolates from the UK.
Department of Medicine, University of Cambridge, Cambridge, UK; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, UK; Royal Veterinary College, Hawkshead Campus, University of London, London, UK; Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, Public Healt...
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The development and maintenance of an arsenal of antibiotics is a major health care challenge. Ceftaroline is a new cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA); however, no reports concerning MRSA ceftaroline susceptibility have been reported in Switzerland. We tested the in vitro activity of ceftaroline against an archived set of 60 MRSA strains from ...
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Ceftaroline and ceftobiprole are two new cephalosporin molecules on which intense studies have been made for the treatments of bacteria most of which are hospital infection factor, especially resistant gram positive cocci. Ceftaroline which has broad Gram-positive activity recently has been approved for clinical uses by the US Food and Drug Administration. Ceftobiprole has been approved for use...
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Vancomycin, linezolid, and daptomycin are very active against staphylococci, but isolates with decreased susceptibility to these antimicrobial agents are isolated sporadically. A total of 19,350 Staphylococcus aureus isolates (51% methicillin resistant [MRSA]) and 3,270 coagulase-negative staphylococci (CoNS) were collected consecutively from 82 U.S. medical centers from January 2008 to Decembe...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2015
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkv325